Publications

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Nagy GN, Zhao XF, Karlsson R, Wang K, Duman R, Harlos K,  El Omari K, Wagner A, Clausen H, Miller RL, Giger RJ, Jones EY
Nature Communications (2024) 
DOI: 10.1038/s41467-024-46725-7
2024
Opine dehydrogenases, an underexplored enzyme family for the enzymatic synthesis of chiral amines
Telek A, Molnár Z, Vértessy BG, Tasnádi G.
Biotechnol Bioeng.
doi: 10.1002/bit.28469
2023
Mechanism-Based Redesign of GAP to Activate Oncogenic Ras
Berta D, Gehrke S, Nyíri K, Vértessy BG, Rosta E.
J Am Chem Soc.
doi: 10.1021/jacs.3c04330
2023
Discovery of two new isoforms of the human DUT gene
Rácz GA, Nagy N, Várady G, Tóvári J, Apáti Á, Vértessy BG.
Sci Rep.
doi: 10.1038/s41598-023-32970-1.
2023
Characterization of the dynamics of Plasmodium falciparum deoxynucleotide-triphosphate pool in a stage-specific manner
Babai R, Izrael R, Vértessy BG.
Sci Rep.
doi: 10.1038/s41598-022-23807-4.
2022
Reducing data dimension boosts neural network-based stage-specific malaria detection
Preißinger K, Kellermayer M, Vértessy BG, Kézsmárki I, Török J.
Sci Rep.
doi: 10.1038/s41598-022-19601-x.
2022
Full-scale demonstration of a floating seal for enhanced biological nutrient removal in a sequencing batch reactor establishing chemical-free environment in wastewater treatment at low carbon source availability
Szombathy P, Nagy KK, Vértessy BG, Jobbágy A.
Environ Technol.
doi: 10.1080/09593330.2022.2111530.
2022
Immobilization of the Aspartate Ammonia-Lyase from Pseudomonas fluorescens R124 on Magnetic Nanoparticles: Characterization and Kinetics
Csuka P, Molnár Z, Tóth V, Imarah AO, Balogh-Weiser D, Vértessy BG, Poppe L.
Chembiochem.
doi: 10.1002/cbic.202100708
2022
Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer
Pálinkás HL, Pongor L, Balajti M, Nagy Á, Nagy K, Békési A, Bianchini G, Vértessy BG, Győrffy B.
Int J Mol Sci.
doi: 10.3390/ijms23020633.
2022
Identification of new reference genes with stable expression patterns for gene expression studies using human cancer and normal cell lines
Rácz GA, Nagy N, Tóvári J, Apáti Á, Vértessy BG.
Sci Rep.
doi: 10.1038/s41598-021-98869-x.
2021
What's in a name? From "fluctuation fit" to "conformational selection": rediscovery of a concept
Orosz F, Vértessy BG.
Hist Philos Life Sci.
doi: 10.1007/s40656-021-00442-2.
2021
Viruses with U-DNA: New Avenues for Biotechnology
Nagy KK, Skurnik M, Vértessy BG.
Viruses
doi: 10.3390/v13050875.
2021 
Detection of Genomic Uracil Patterns
Békési A, Holub E, Pálinkás HL, Vértessy BG.
Int J Mol Sci.
doi: 10.3390/ijms22083902.
2021
An open chat with Beata Vertessy
Tsagakis I, Vertessy B, Wright D.
FEBS Open Bio.
doi: 10.1002/2211-5463.13077
2021
Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments.
Petri L, Ábrányi-Balogh P, Tímea I, Pálfy G, Perczel A, Knez D, Hrast M, Gobec M, Sosič I, Nyíri K, Vértessy BG, Jänsch N, Desczyk C, Meyer-Almes FJ, Ogris I, Golič Grdadolnik S, Iacovino LG, Binda C, Gobec S, Keserű GM.
Chembiochem.
doi: 10.1002/cbic.202000700
2021
Structure-based inhibitor design of mutant RAS proteins-a paradigm shift.
Nyíri K, Koppány G, Vértessy BG.Cancer
Metastasis Rev.
doi: 10.1007/s10555-020-09914-6.
2020
Identification of a nuclear localization signal in the Plasmodium falciparum CTP: phosphocholine cytidylyltransferase enzyme.
Izrael R, Marton L, Nagy GN, Pálinkás HL, Kucsma N, Vértessy BG.
Sci Rep.
doi: 10.1038/s41598-020-76829-1
2020
Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments.
Pálinkás HL, Békési A, Róna G, Pongor L, Papp G, Tihanyi G, Holub E, Póti Á, Gemma C, Ali S, Morten MJ, Rothenberg E, Pagano M, Szűts D, Győrffy B, Vértessy BG.
Elife.
doi: 10.7554/eLife.60498
2020
Rapid and quantitative antimalarial drug efficacy testing via the magneto-optical detection of hemozoin.
Molnár P, Orbán Á, Izrael R, Babai R, Marton L, Butykai Á, Karl S, Vértessy BG, Kézsmárki I.
Sci Rep.
doi: 10.1038/s41598-020-70860-y
2020
Structure-based inhibitor design of mutant RAS proteins-a paradigm shift.
Nyíri K, Koppány G, Vértessy BG.
;Cancer Metastasis Rev.
doi: 10.1007/s10555-020-09914-6
2020
A user-friendly, high-throughput tool for the precise fluorescent quantification of deoxyribonucleoside triphosphates from biological samples.
Szabó JE, Surányi ÉV, Mébold BS, Trombitás T, Cserepes M, 
Nucleic Acids Res.
doi: 10.1093/nar/gkaa116
2020
An Acridone‐Based Fluorescent Chemosensor for Cationic and Anionic Species, and Its Application for Molecular Logic Operations
D Pál, P Baranyai, I Leveles, BG Vértessy, P Huszthy, I Móczár
ChemistrySelect
doi: 10.1002/slct.201903483
2019
Unshielding multidrug resistant cancer through selective iron depletion of P-glycoprotein expressing cells.
Cserepes M, Türk D, Tóth S, Pape VFS, Gaál A, Gera M, Szabó JE, Kucsma N, Várady G, Vértessy BG, Streli C, Szabó PT, Tovari J, Szoboszlai N, Szakács G.
Cancer Res
doi: 10.1158/0008-5472.CAN-19-1407
2019
Allele-specific inhibitors of mutant KRAS are in the focus of RASopathy consortium.
Nyíri K, Koppány G, Pálfy G, Vida I, Tóth S, Orgován Z, Ranđelović I, Baranyi M, Molnár E, Keserû MG, Tóvári J, Perczel A, Vértessy BG, Tímár J.
Magyar Onkologia
2019 Dec 9;63(4):310-323. Epub 2019 Nov 25. Hungarian.
2019
Beyond Chelation: EDTA Tightly Binds Taq DNA Polymerase, MutT and dUTPase and Directly Inhibits dNTPase Activity.
Lopata A, Jójárt B, Surányi ÉV, Takács E, Bezúr L, Leveles I, Bendes ÁÁ, Viskolcz B, Vértessy BG, Tóth J.
Biomolecules
doi: 10.3390/biom9100621.
2019
Highly Sensitive and Rapid Characterization of the Development of Synchronized Blood Stage Malaria Parasites Via Magneto-Optical Hemozoin Quantification.Pukáncsik M, Molnár P, Orbán Á, Butykai Á, Marton L, Kézsmárki I, Vértessy BG, Kamil M, Abraham A, Aly ASI.
Biomolecules
doi: 10.3390/biom9100579
2019
HDX and Native Mass Spectrometry Reveals the Different Structural Basis for Interaction of the Staphylococcal Pathogenicity Island Repressor Stl with Dimeric and Trimeric Phage dUTPases.
Nyíri K, Harris MJ, Matejka J, Ozohanics O, Vékey K, Borysik AJ, Vértessy BG.
Biomolecules
doi: 10.3390/biom9090488.
2019
The Role of a Key Amino Acid Position in Species-Specific Proteinaceous dUTPase Inhibition.
Benedek A, Temesváry-Kis F, Khatanbaatar T, Leveles I, Surányi ÉV, Szabó JE, Wunderlich L, Vértessy BG.

Biomolecules
doi: 10.3390/biom9060221.
2019
Search and destroy: versatile proteins offer unique structural solutions against uracil in DNA
Vértessy BG.

Amino Acids, Peptides and Proteins,
doi: 10.1039/9781788013857-00001.
2019
Evaluation of critical design parameters for RT-qPCR-based analysis of multiple dUTPase isoform genes in mice.
Rácz GA, Nagy N, Gál Z, Pintér T, Hiripi L, Vértessy BG.

FEBS Open Bio.
doi: 10.1002/2211-5463.12654.
2019
CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality
Pálinkás HL, Rácz GA, Gál Z, Hoffmann OI, Tihanyi G, Róna G, Gócza E, Hiripi L, Vértessy BG

Biomolecules
doi: 10.3390/biom9040136.
 2019
Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions
Merő B, Radnai L, Gógl G, Tőke O, Leveles I, Koprivanacz K, Szeder B, Dülk M, Kudlik G, Vas V, Cserkaszky A, Sipeki S, Nyitray L, Vértessy BG, Buday L.
J Biol Chem
doi: 10.1074/jbc.RA118.004732
 2019

Mass spectrometry-based analysis of macromolecular complexes of Staphylococcus aureusuracil-DNA glycosylase and its inhibitor reveals specific variations due to naturally occurring mutations
Papp-Kádár V, Balázs Z, Vékey K, Ozohanics O, Vértessy BG

FEBS Open Bio
doi: 10.1002/2211-5463.12567

 2019
The role of enzyme adsorption in the enzymatic degradation of an aliphatic polyester
Polyák P, Urbán E, Nagy GN, Vértessy BG, Pukánszky B

Enzyme Microb Technol.
doi: 10.1016/j.enzmictec.2018.10.005
 2019
Uracil moieties in Plasmodium falciparum genomic DNA
Molnár P, Marton L, Izrael R, Pálinkás HL, Vértessy BG
FEBS Open Bio
doi: 10.1002/2211-5463.12458
 2018
Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis
Guca E, Nagy GN, Hajdú F, Marton L, Izrael R, Hoh F, Yang Y, Vial H, Vértessy BG, Guichou JF, Cerdan R
Scientific Reports
doi: 10.1038/s41598-018-29500-9
2018
Heterologous expression of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum rescues Chinese Hamster Ovary cells deficient in the Kennedy phosphatidylcholine biosynthesis pathway
Marton L, Hajdú F, Nagy GN, Kucsma N, Szakács G, Vértessy BG
Scientific Reports
doi: 10.1038/s41598-018-27183-w
2018
Enzymatic degradation of poly-[(R)-3-hydroxybutyrate]: Mechanism, kinetics, consequences
Polyák P, Dohovits E, Nagy GN, Vértessy BG, Vörös G, Pukánszky B
International Journal of Biological Macromolecules
doi: 10.1016/j.ijbiomac.2018.01.104
2018
Exploiting a Phage-Bacterium Interaction System as a Molecular Switch to Decipher Macromolecular Interactions in the Living Cell
Surányi ÉV, Hírmondó R, Nyíri K, Tarjányi S, Kőhegyi B, Tóth J, Vértessy BG
Viruses
doi: 10.3390/v10040168
2018
Structural model of human dUTPase in complex with a novel proteinaceous inhibitor
Nyíri K, Mertens HDT, Tihanyi B, Nagy GN, Kőhegyi B, Matejka J, Harris MJ, Szabó JE, Papp-Kádár V, Németh-Pongrácz V, Ozohanics O, Vékey K, Svergun DI,
Borysik AJ, Vértessy BG
Scientific Reports
doi: 10.1038/s41598-018-22145-8
2018
The Fourth Wave of Biocatalysis Emerges- The 13 th International Symposium on Biocatalysis and Biotransformations
Poppe L, Vértessy BG
Chembiochem
doi: 10.1002/cbic.201700687
2018
The Stl repressor from Staphylococcus aureus is an efficient inhibitor of the eukaryotic fruitfly dUTPase
Benedek A, Pölöskei I, Ozohanics O, Vékey K, Vértessy BG
FEBS Open Bio
doi: 10.1002/2211-5463.12302
2017
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells
Periyasamy M, Singh AK, Gemma C, Kranjec C, Farzan R, Leach DA, Navaratnam N, Pálinkás HL, Vértessy BG, Fenton TR, Doorbar J, Fuller-Pace F, Meek DW, Coombes RC, Buluwela L, Ali S
Nucleic Acids Research
doi: 10.1093/nar/gkx721
2017
Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding
Ecsédi P, Kiss B, Gógl G, Radnai L, Buday L, Koprivanacz K, Liliom K, Leveles I, Vértessy B, Jeszenői N, Hetényi C, Schlosser G, Katona G, Nyitray L
Structure
doi: 10.1016/j.str.2017.06.001
2017
A viral suppressor of RNA silencing inhibits ARGONAUTE 1 function by precluding target RNA binding to pre-assembled RISC
Kenesi E, Carbonell A, Lózsa R, Vértessy B, Lakatos L
Nucleic Acids Research
doi: 10.1093/nar/gkx379
2017
Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymes
Hirmondo R, Lopata A, Suranyi EV, Vertessy BG, Toth J
Scientific Reports
doi: 10.1038/s41598-017-06206-y
2017
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells
Nikkilä J, Kumar R, Campbell J, Brandsma I, Pemberton HN, Wallberg F, Nagy K, Scheer I, Vertessy BG, Serebrenik AA, Monni V, Harris RS, Pettitt SJ,
Ashworth A, Lord CJ
British journal of cancer
doi: 10.1038/bjc.2017.133
2017
The First Enantioselective Total Synthesis of (-)-trans-Dihydronarciclasine
Varró G, Hegedűs L, Simon A, Balogh A, Grün A, Leveles I, Vértessy BG, Kádas I
Journal of natural products
doi: 10.1021/acs.jnatprod.7b00208
2017
A Methylidene Group in the Phosphonic Acid Analogue of Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine Ammonia-Lyases
Bata Z, Qian R, Roller A, Horak J, Bencze LC, Paizs C, Hammerschmidt F, Vértessy BG, Poppe L
Advanced Synthesis & Catalysis
doi: 10.1002/adsc.201700428
2017
The novel technique of vapor pressure analysis to monitor the enzymatic degradation of PHB by HPLC chromatography
Polyák P, Rácz P, Rózsa P, Nagy GN, Vértessy BG, Pukánszky B
Analytical Biochemistry
doi: 10.1016/j.ab.2017.01.004
2017
Identification of Extracellular Segments by Mass Spectrometry Improves Topology Prediction of Transmembrane Proteins
Langó T, Róna G, Hunyadi-Gulyás É, Turiák L, Varga J, Dobson L, Várady G, Drahos L, Vértessy BG, Medzihradszky KF, Szakács G, Tusnády GE
Scientific Reports
doi: 10.1038/srep42610
2016
A Hidden Active Site in the Potential Drug Target Mycobacterium tuberculosis dUTPase Is Accessible through Small Amplitude Protein Conformational Changes
Lopata A, Leveles I, Bendes ÁÁ, Viskolcz B, Vértessy BG, Jójárt B, Tóth J
The Journal of biological chemistry
doi: 10.1074/jbc.M116.734012
2016
Structural Characterization of Arginine Fingers: Identification of an Arginine Finger for the Pyrophosphatase dUTPases
Nagy GN, Suardíaz R, Lopata A, Ozohanics O, Vékey K, Brooks BR, Leveles I, Tóth J, Vértessy BG, Rosta E
Journal of the American Chemical Society
doi: 10.1021/jacs.6b09012
2016
Correction: Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase
Marton L, Nagy GN, Ozohanics O, Lábas A, Krámos B, Oláh J, Vékey K, Vértessy BG
PLoS One
doi: 10.1371/journal.pone.0165871
2016
The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine
Requena CE, Pérez-Moreno G, Horváth A, Vértessy BG, Ruiz-Pérez LM, González-Pacanowska D, Vidal AE
The Biochemical Journal
doi: 10.1042/BCJ20160302
2016
Potential steps in the evolution of a fused trimeric all-β dUTPase involve a catalytically competent fused dimeric intermediate
Benedek A, Horváth A, Hirmondó R, Ozohanics O, Békési A, Módos K, Révész Á, Vékey K, Nagy GN, Vértessy BG.
FEBS Journal
doi: 10.1111/febs.13800
2016
In Vitro Analysis of Predicted DNA-Binding Sites for the Stl Repressor of the Staphylococcus aureus SaPIBov1 Pathogenicity Island
V Papp-Kádár, JE Szabo, K Nyíri, BG Vertessy
PLoS One 
doi: 10.1371/journal.pone.0158793
2016
Structural Biology and Regulation of Protein Import into the Nucleus
M Christie, CW Chang, G Róna, KM Smith, AG Stewart, AA Takeda, MR Fontes, M Stewart, BG Vértessy, JK Forwood, B Kobe
Journal of molecular biology 
doi: 10.1016/j.jmb.2015.10.023
2016
Perturbation of genome integrity to fight pathogenic microorganisms
K Nyíri, BG Vértessy
Biochimica et Biophysica Acta (BBA)-General Subjects
doi:10.1016/j.bbagen.2016.05.024
2016
Secondary Structure Prediction of Protein Constructs Using Random Incremental Truncation and Vacuum-Ultraviolet CD Spectroscopy
M Pukáncsik, Á Orbán, K Nagy, K Matsuo, K Gekko, D Maurin, D Hart, I Kézsmárki, BG. Vertessy
doi: 10.1371/journal.pone.0156238  
2016
Trading in cooperativity for specificity to maintain uracil-free DNA
JE Szabó, E Takács, G Merényi, BG Vértessy, J Tóth
Scientific Reports 6, Article number: 24219
doi:10.1038/srep24219
2016
Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ...
Autophagy 12 (1), 1-222
2016
Exploring the role of the phage-specific insert of bacteriophage Φ11 dUTPase
K Nyíri, V Papp-Kádár, JE Szabó, V Németh, BG Vértessy
Structural Chemistry 26 (5-6), 1425-1432
2015
Structural characterization of a complex derived from lead (II) perchlorate and acridono-18-crown-6 ether
T Németh, Á Golcs, I Leveles, T Tóth, BG Vértessy, P Huszthy
Structural Chemistry 26 (5-6), 1467-1471
2015
Cover Picture: Phenylalanine Ammonia‐Lyase‐Catalyzed Deamination of an Acyclic Amino Acid: Enzyme Mechanistic Studies Aided by a Novel Microreactor Filled with Magnetic Nanoparticles (ChemBioChem 16/2015)
D Weiser, LC Bencze, G Bánóczi, F Ender, R Kiss, E Kókai, A Szilágyi, ...
ChemBioChem 16 (16), 2257-2257
2015
Phenylalanine Ammonia‐Lyase‐Catalyzed Deamination of an Acyclic Amino Acid: Enzyme Mechanistic Studies Aided by a Novel Microreactor Filled with Magnetic Nanoparticles
D Weiser, LC Bencze, G Bánóczi, F Ender, R Kiss, E Kókai, A Szilágyi, ...
ChemBioChem 16 (16), 2283-2288
2015
Structural biology and regulation of protein import into the nucleus
M Christie, CW Chang, G Róna, KM Smith, AG Stewart, AAS Takeda, ...
Journal of molecular biology
2015
Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications
G Róna, I Scheer, K Nagy, HL Pálinkás, G Tihanyi, M Borsos, A Békési, ...
Nucleic acids research, gkv977
2015
Evidence-based structural model of the Staphylococcal repressor protein: separation of functions into different domains
K Nyíri, B Kőhegyi, A Micsonai, J Kardos, BG Vertessy
PloS one 10 (9), e0139086
2015
Life without dUTPase
Kerepesi C, Szabó JE, Papp-Kádár V, Dobay O, Szabó D, Grolmusz V, Vértessy BG
Frontiers in microbiology
2016
Cross-species inhibition of dUTPase via the Staphylococcal Stl protein perturbs dNTP pool and colony formation in Mycobacterium
R Hirmondó, JE Szabó, K Nyíri, S Tarjányi, P Dobrotka, J Tóth, ...
DNA repair 30, 21-27
2015
Antimycobacterial activity of peptide conjugate of pyridopyrimidine derivative against Mycobacterium tuberculosis in a series of in vitro and in vivo models
K Horváti, B Bacsa, N Szabó, K Fodor, G Balka, M Rusvai, É Kiss, G Mező, ...
Tuberculosis 95, S207-S211
2015
Molecular mechanism for the thermo-sensitive phenotype of CHO-MT58 cell line harbouring a mutant CTP: phosphocholine cytidylyltransferase
L Marton, GN Nagy, O Ozohanics, A Lábas, B Krámos, J Oláh, K Vékey, ...
PloS one 10 (6), e0129632
2015
dUTPase expression correlates with cell division potential in Drosophila melanogaster
A Horváth, J Batki, L Henn, T Lukacsovich, G Róna, M Erdélyi, ...
FEBS Journal 282 (10), 1998-2013
2015
Mutations decouple proton transfer from phosphate cleavage in the dutpase catalytic reaction
A Lopata, PG Jambrina, PK Sharma, BR Brooks, J Toth, BG Vertessy, ...
ACS Catalysis 5 (6), 3225-3237
2015
Immobilization of Phenylalanine Ammonia‐Lyase on Single‐Walled Carbon Nanotubes for Stereoselective Biotransformations in Batch and Continuous‐Flow Modes
JH Bartha‐Vári, MI Toşa, FD Irimie, D Weiser, Z Boros, BG Vértessy, ...
ChemCatChem 7 (7), 1122-1128
2015
NLS copy‐number variation governs efficiency of nuclear import–case study on dUTPases
G Róna, HL Pálinkás, M Borsos, A Horváth, I Scheer, A Benedek, ...
FEBS Journal 281 (24), 5463-5478
2014
Composite aromatic boxes for enzymatic transformations of quaternary ammonium substrates
GN Nagy, L Marton, A Contet, O Ozohanics, LM Ardelean, Á Révész, ...
Angewandte Chemie International Edition 53 (49), 13471-13476
2014
Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation
G Róna, M Borsos, JJ Ellis, AM Mehdi, M Christie, Z Környei, M Neubrandt, ...
Cell cycle 13 (22), 3551-3564
2014
Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control
JE Szabó, V Németh, V Papp-Kádár, K Nyíri, I Leveles, ÁÁ Bendes, ...
Nucleic acids research 42 (19), 11912-11920
2014
Factors influencing nucleo-cytoplasmic trafficking: which matter? Response to Alvisi & Jans' comment on Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights
G Róna, M Borsos, B Kobe, BG Vértessy
Acta Crystallographica Section D: Biological Crystallography 70 (10), 2777-2778
2014
Insights into the catalytic mechanism of PfECT by thermodynamic, kinetic and structural analyses
A Contet, S Maheshwari, E Pihan, GN Nagy, B Vertessy, D Douguet, ...
FEBS JOURNAL 281, 574-575
2014
Preventive DNA repair by sanitizing the cellular (deoxy) nucleoside triphosphate pool
GN Nagy, I Leveles, BG Vértessy
FEBS Journal 281 (18), 4207-4223
2014
The metagenomic telescope
B Szalkai, I Scheer, K Nagy, BG Vertessy, V Grolmusz
PloS one 9 (7), e101605
2014
Bisepoxide Cross‐Linked Enzyme Aggregates—New Immobilized Biocatalysts for Selective Biotransformations
D Weiser, A Varga, K Kovács, F Nagy, A Szilágyi, BG Vértessy, C Paizs, ...
ChemCatChem 6 (5), 1463-1469
2014
Expression and properties of the highly alkalophilic phenylalanine ammonia-lyase of thermophilic Rubrobacter xylanophilus
K Kovacs, G Banoczi, A Varga, I Szabo, A Holczinger, G Hornyanszky, ...
PloS one 9 (1), e85943
2014
A preventív DNS-hibajavítás szerkezeti biológiája
G Vértessy
MAGYAR KÉMIAI FOLYÓIRAT-KÉMIAI KÖZLEMÉNYEK 120 (4), 176-177
2014
Structure and enzymatic mechanism of a moonlighting dUTPase
I Leveles, V Németh, JE Szabó, V Harmat, K Nyíri, ÁÁ Bendes, ...
Acta Crystallographica Section D: Biological Crystallography 69 (12), 2298-2308
2013
Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights
G Róna, M Marfori, M Borsos, I Scheer, E Takács, J Tóth, F Babos, ...
Acta Crystallographica Section D: Biological Crystallography 69 (12), 2495-2505
2013
Investigations of homologous disaccharides by elastic incoherent neutron scattering and wavelet multiresolution analysis
S Magazù, F Migliardo, BG Vertessy, MT Caccamo
Chemical Physics 424, 56-61
2013
Protein dynamics by neutron scattering: The protein dynamical transition and the fragile-to-strong dynamical crossover in hydrated lysozyme
S Magazù, F Migliardo, A Benedetto, B Vertessy
Chemical Physics 424, 26-31
2013
Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling
O Barabás, V Németh, A Bodor, A Perczel, E Rosta, Z Kele, I Zagyva, ...
Nucleic acids research, gkt756
2013
Genomic integrity of virulence genes is preserved by a dUTPase-based molecular switch
J Szabo, V Nemeth, V Papp-Kadar, K Nyiri, I Leveles, A Bendes, ...
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 42, S134-S134
2013
Evolutionary and mechanistic insights into substrate and product accommodation of CTP: phosphocholine cytidylyltransferase from Plasmodium falciparum
GN Nagy, L Marton, B Krámos, J Oláh, Á Révész, K Vékey, F Delsuc, ...
FEBS Journal 280 (13), 3132-3148
2013
Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis
A Butykai, A Orbán, V Kocsis, D Szaller, S Bordács, E Tátrai-Szekeres, ...
Scientific reports 3
2013
Nanomechanics of the MPMV Capsid-Protein-Binding RNA Fragment
M Simon, Z Martonfalvi, P Bianco, B Vertessy, MSZ Kellermayer
Biophysical Journal 104 (2), 168a-169a
2013
Silicon carbide quantum dots for bioimaging
D Beke, Z Szekrényes, D Pálfi, G Róna, I Balogh, PA Maák, G Katona, ...
Journal of Materials Research 28 (02), 205-209
2013
Egy tudományos hungarikum: a fluktuációs fit
F Orosz, G Vértessy
Magyar Tudomány 174 (2), 170-175
2013
An inter-species landscape of DNA repair proteins based on extreme metagenomes and repeated HMM profiling
V Grolmusz, B Szalkai, G Vértessy, I Scher
FEBS Journal 280 (Supl 1), 66
2013
dUTPase based switch controls transfer of virulence genes in order to preserve integrity of the transferred mobile genetic elements
JE Szabó, V Németh-Pongrácz, V Papp-Kádár, K Nyíri, B Besztercei, ...
FEBS Journal 280 (Supl 1), 59-60
2013
The impact of dUTPase expression on genome integrity
A Horváth, J Batki, V Muha, G Róna, P Vilmos, M Erdélyi, G Vértessy
FEBS Journal 280 (Supl 1), 58-59
2013
Molecular cloning and characterization of a thermostable esterase/lipase produced by a novel Anoxybacillus flavithermus strain
L Chiş, F Hriscu, M, Bica, A, Toşa, M, Nagy, Gergely, Róna
J Gen Appl Microbiol. 59 (2), 119-134
2013
Expanding the DNA alphabet in the fruit fly: Uracil enrichment in genomic DNA
A Horváth, A Békési, V Muha, M Erdélyi, BG Vértessy
Fly 7 (1), 23-27
2013
Molecular Mechanisms of Survival Strategies in Extreme Conditions
S Magazù, F Migliardo, MA Gonzalez, C Mondelli, SF Parker, BG Vertessy
Life 2 (4), 364-376
2012
Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement
V Muha, A Horváth, A Békési, M Pukáncsik, B Hodoscsek, G Merényi, ...
PLoS Genet 8 (6), e1002738
2012
The dUTPase enzyme is essential in Mycobacterium smegmatis
I Pecsi, R Hirmondo, AC Brown, A Lopata, T Parish, BG Vertessy, J Tóth
PLoS One 7 (5), e37461
2012
Enhanced cellular uptake of a new, in silico identified antitubercular candidate by peptide conjugation
K Horváti, B Bacsa, N Szabó, S Dávid, G Mező, V Grolmusz, B Vértessy, ...
Bioconjugate chemistry 23 (5), 900-907
2012
Preparation of unnatural amino acids with ammonia-lyases and 2, 3-aminomutases
L Poppe, C Paizs, K Kovács, FD Irimie, B Vértessy
Unnatural Amino Acids: Methods and Protocols, 3-19
2012
Discovery of novel MDR-Mycobacterium tuberculosis inhibitor by new FRIGATE computational screen
C Scheich, Z Szabadka, B Vértessy, V Pütter, V Grolmusz, M Schade
PloS one 6 (12), e28428
2011
Crystallization and preliminary crystallographic analysis of dUTPase from the φ11 helper phage of Staphylococcus aureus
I Leveles, G Róna, I Zagyva, A Bendes, V Harmat, BG Vértessy
Acta Crystallographica Section F: Structural Biology and Crystallization ...
2011
One-step method for quantitative determination of uracil in DNA by real-time PCR
BG Vertessy, A Horvath, V Grolmusz
US Patent App. 13/237,987
2011
Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination
I Pécsi, JE Szabó, SD Adams, I Simon, JR Sellers, BG Vértessy, J Tóth
Proceedings of the National Academy of Sciences 108 (35), 14437-14442
2011
Nanomechanical manipulation of Mason-Pfizer monkey retroviral RNA fragment with optical tweezers
M Simon, Z Martonfalvi, P Bianco, B Vertessy, M Kellermayer
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 40, 223-223
2011
Proteins with Complex Architecture as Potential Targets for Drug Design: A Case Study of Mycobacterium tuberculosis
B Mészáros, J Tóth, BG Vértessy, Z Dosztányi, I Simon
PLoS Comput Biol 7 (7), e1002118
2011
Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism
G Merényi, J Kovári, J Tóth, E Takács, I Zagyva, A Erdei, BG Vértessy
Nucleosides, Nucleotides and Nucleic Acids 30 (6), 369-390
2011
Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide
Z Bozóky, G Róna, É Klement, KF Medzihradszky, G Merényi, ...
PloS one 6 (5), e19546
2011
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans
P Erdélyi, É Borsos, K Takács-Vellai, T Kovács, AL Kovács, T Sigmond, ...
Journal of cell science 124 (9), 1510-1518
2011
Humán dUTPáz: kooperativitás és sejtbeli kölcsönhatások= Human dUTPase: cooperativity and cellular interactions
G Vértessy, O Barabás, A Horváth, A Málnási Csizmadia, V Németh, ...
OTKA Kutatási Jelentések| OTKA Research Reports
2011
Association of RNA with the uracil‐DNA‐degrading factor has major conformational effects and is potentially involved in protein folding
A Bekesi, M Pukancsik, P Haasz, L Felfoldi, I Leveles, V Muha, ...
FEBS journal 278 (2), 295-315
2011
From “fluctuation fit” to “conformational selection”: evolution, rediscovery, and integration of a concept
BG Vertessy, F Orosz
Bioessays 33 (1), 30-34
2011
EXPRESSION OF PHENYLALANINE AMMONIA-LYASES IN ESCHERICHIA COLI STRAINS.
K Kovács, A Holczinger, B Vértessy, L Poppe
Studia Universitatis Babes-Bolyai, Chemia
2010
A one-step method for quantitative determination of uracil in DNA by real-time PCR
A Horváth, BG Vértessy
Nucleic acids research 38 (21), e196-e196
2010
Structure and mechanism of calmodulin binding to a signaling sphingolipid reveal new aspects of lipid-protein interactions
E Kovacs, V Harmat, J Tóth, BG Vértessy, K Módos, J Kardos, K Liliom
The FASEB Journal 24 (10), 3829-3839
2010
Sphingosylphosphorylcholine Binds to Calmodulin and Inhibits Its Function
E Kovacs, V Harmat, J Toth, B Vertessy, K Modos, J Kardos, K LILIOM
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 382, 20-20
2010
Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases
E Takács, G Nagy, I Leveles, V Harmat, A Lopata, J Tóth, BG Vértessy
FEBS letters 584 (14), 3047-3054
2010
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase
I Pecsi, I Leveles, V Harmat, BG Vertessy, J Toth
Nucleic acids research, gkq584
2010
Drosophila proteins involved in metabolism of uracil‐DNA possess different types of nuclear localization signals
G Merényi, E Kónya, BG Vértessy
FEBS journal 277 (9), 2142-2156
2010
Physiological truncation and domain organization of a novel uracil‐DNA‐degrading factor
M Pukáncsik, A Békési, É Klement, É Hunyadi‐Gulyás, KF Medzihradszky, ...
FEBS journal 277 (5), 1245-1259
2010
Study of solvent–protein coupling effects by neutron scattering
B Varga, F Migliardo, E Takacs, B Vertessy, S Magazù, MTF Telling
Journal of biological physics 36 (2), 207-220
2010
The Role of P-loop in the Enzymatic Mechanism of Nucleotide Pyrophosphatases
I Pecsi, JE Szabo, BG Vertessy, J Toth
Biophysical Journal 98 (3), 449a
2010
Phosphorylation Dependent Nuclear Transport of Human Dutpase
G Rona, E Takacs, Z Bozoky, Z Kornyei, M Neubrandt, J Toth, I Scheer, ...
Biophysical Journal 98 (3), 309a
2010
Peculiar Regulatory Role of Magnesium in Nucleotide Hydrolysis of dUTPases
E Takacs, BG Vertessy, J Toth
Biophysical Journal 98 (3), 451a
2010
New Aspects of Lipid-Protein Interactions Revealed by Calmodulin Binding to the Lipid Mediator Sphingosylphosphorylcholine
E Kovacs, V Harmat, J Toth, BG Vertessy, K Modos, J Kardos, K Liliom
Biophysical Journal 98 (3), 675a
2010
Dissociation of Calmodulin-Target Peptide Complexes by the Lipid Mediator Sphingosylphosphorylcholine IMPLICATIONS IN CALCIUM SIGNALING
E Kovacs, J Tóth, BG Vértessy, K Liliom
Journal of Biological Chemistry 285 (3), 1799-1808
2010
Ansari MA, 341 Arnold U, 331 Arora A, 341
RG Atkinson, W Becker, F Beisson, A Bekesi, H Benyamini, A Bergemann, ...
FEBS Journal 278, 401
2010
Nuclear localization signal-dependent and-independent movements of Drosophila melanogaster dUTPase isoforms during nuclear cleavage
V Muha, I Zagyva, Z Venkei, J Szabad, BG Vértessy
Biochemical and biophysical research communications 381 (2), 271-275
2009
Molecular shape and prominent role of β-strand swapping in organization of dUTPase oligomers
E Takács, O Barabás, MV Petoukhov, DI Svergun, BG Vértessy
FEBS letters 583 (5), 865-871
2009
Improving thermostability and catalytic activity of pyranose 2‐oxidase from Trametes multicolor by rational and semi‐rational design
O Spadiut, C Leitner, C Salaheddin, B Varga, BG Vertessy, TC Tan, ...
Febs Journal 276 (3), 776-792
2009
Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases
BG Vértessy, J Tóth
Accounts of chemical research 42 (1), 97-106
2008
Experimental study on dUTPase-inhibitor candidate and dUTPase/disaccharide mixtures by PCS and ENS
B Varga, F Migliardo, E Takacs, B Vertessy, S Magazù
Journal of Molecular Structure 886 (1), 128-135
2008
Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor
B Varga, O Barabás, E Takács, N Nagy, P Nagy, BG Vértessy
Biochemical and biophysical research communications 373 (1), 8-13
2008
Peptide conjugates of new in silico identified drug candidates and first/second line antituberculars-design, synthesis and antimycobacterial effect
K Horvati, G Mezo, N Szabo, B Vertessy, B Varga, V Grolmusz, F Hudecz, ...
JOURNAL OF PEPTIDE SCIENCE 14 (8), 161-161
2008
Neutron scattering studies on dUTPase complex in the presence of bioprotectant systems
B Varga, F Migliardo, E Takacs, B Vertessy, S Magazù, C Mondelli
Chemical Physics 345 (2), 250-258
2008
Methylene substitution at the α–β bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site
J Kovári, O Barabás, B Varga, A Békési, F Tölgyesi, J Fidy, J Nagy, ...
Proteins: Structure, Function, and Bioinformatics 71 (1), 308-319
2008
Amphiphilic nature of new antitubercular drug candidates and their interaction with lipid monolayer
K Hill, CB Pénzes, BG Vértessy, Z Szabadka, V Grolmusz, É Kiss
Colloids for Nano-and Biotechnology, 87-92
2008
Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme
J Tóth, B Varga, M Kovács, A Málnási-Csizmadia, BG Vértessy
Journal of Biological Chemistry 282 (46), 33572-33582
2007
Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase
B Varga, O Barabás, J Kovári, J Tóth, É Hunyadi-Gulyás, É Klement, ...
FEBS letters 581 (24), 4783-4788
2007
A novel fruitfly protein under developmental control degrades uracil-DNA
A Békési, M Pukáncsik, V Muha, I Zagyva, I Leveles, E Hunyadi-Gulyás, ...
Biochemical and biophysical research communications 355 (3), 643-648
2007
Fémek szerepe a fehérjeszerkezetben és-működésben= The role of metals in protein structure and function
G Náray-Szabó, O Barabás, I Berente, A Czajlik, V Farkas, J Fidy, ...
OTKA Kutatási Jelentések| OTKA Research Reports
2007
Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins
V Nemeth-Pongracz, O Barabas, M Fuxreiter, I Simon, I Pichová, ...
Nucleic acids research 35 (2), 495-505
2007
Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance
SU Lari, CY Chen, BG Vertéssy, J Morré, SE Bennett
DNA repair 5 (12), 1407-1420
2006
INOR 451-Kinetic effects of vanadium compounds on human dUTPase, the enzyme responsible for DNA integrity and involved in cancer cell survival
I Zagyva, O Barabas, J Smee, DC Crans, B Vertessy
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 232
2006
Characterization of the nuclease responsible for uracil-DNA signalling in drosophila melanogaster
M Pukancsik, A Bekesi, F Felfoldi, I Zagyva, F Medzihradszky, G Vertessy
FEBS JOURNAL 273, 114-114
2006
Cooperativity in human dUTPase homotrimer
B Varga, J Kovari, O Barabas, E Takacs, A Malnasi-Csizmadia, ...
FEBS JOURNAL 273, 192-192
2006
Puzzles in formation of trimeric dUTPases
E Takacs, A Bekesi, B Vertessy
FEBS JOURNAL 273, 309-309
2006
dUTpase MRNA silencing triggers apoptosis in cancer cells
J Kovari, I Zagyva, G Merenyi, BG Vertessy
FEBS JOURNAL 273, 113-113
2006
A new family of nucleases: the uracil-DNA-specific nuclease of pupating insects
A Bekesi, F Felfoldi, M Pukancsik, V Maha, I Zagyva, I Leveles, ...
FEBS JOURNAL 273, 53-53
2006
A retroviral dUTPase: modulatory effect of flexible segments on protein structure and function
V Nemeth, O Barabas, M Fuxreiter, D Svergun, M Petoukhov, BG Vertessy
FEBS JOURNAL 273, 312-312
2006
Interacting partners of M-PMV nucleocapsid-dUTPase
V Nemeth-Pongracz, J Snasel, M Rumlova, I Pichova, BG Vertessy
Nucleosides, Nucleotides and Nucleic Acids 25 (9-11), 1197-1200
2006
Crystallization and preliminary X-ray studies of dUTPase from Mason–Pfizer monkey retrovirus
O Barabás, V Németh, BG Vértessy
Acta Crystallographica Section F: Structural Biology and Crystallization …
2006
Synthesis of URACIL-DNA specific endonuclease derived peptides for generation of enzyme specific antibodies
M Ligeti, A Bekesi, A Magyar, F Hudecz, BG Vertessy
Journal of Peptide Science 12, 155-155
2006
Role of the C-terminal conserved sequence motif in the function of dUTPase from Mason-Pfizer monkey retrovirus
O Barabas, V Nemeth-Pongracz, A Magyar, F Hudecz, B Vértessy
J. Pept. Sci 12, 206
2006
Same fold but altered responsivity in the evolution of dUTPase homotrimer
E Takacs, O Barabas, D Svergun, Z Dubrovay, VK Grolmusz, B Vertessy
FEBS JOURNAL 272, 100-100
2005
Uracil-DNA nuclease: protein enzyme possessing nuclease activity specific for uracil containing nucleic acid, process for its preparation and methods of use
BG Vertessy, A Beke, F Felfoldi, VI Grolmusz, M Pukancsik
US Patent App. 11/160,040
2005
Mechanistic studies of dUTPases
J Kovári, T Imre, P Szabó, BG Vértessy
Nucleosides, Nucleotides and Nucleic Acids 23 (8-9), 1475-1479
2004
Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase
O Barabás, V Pongrácz, J Kovári, M Wilmanns, BG Vértessy
Journal of Biological Chemistry 279 (41), 42907-42915
2004
Experimental observation of the pentacovalent intermediate in dUTPase: structural snapshots along the reaction coordinate
O Barábas, V Pongrácz, J Kovári, M Wilmanns, BG Vértessy
Acta Crystallographica Section A: Foundations of Crystallography 60 (a1 …
2004
A tradeoff between protein stability and conformational mobility in homotrimeric dUTPases
E Takács, VK Grolmusz, BG Vértessy
FEBS letters 566 (1-3), 48-54
2004
Developmental regulation of dUTPase in Drosophila melanogaster
A Békési, I Zagyva, É Hunyadi-Gulyás, V Pongrácz, J Kovári, ÁO Nagy, …
Journal of Biological Chemistry 279 (21), 22362-22370
2004
Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer
Z Dubrovay, Z Gáspári, É Hunyadi-Gulyás, KF Medzihradszky, A Perczel, …
Journal of Biological Chemistry 279 (17), 17945-17950
2004
Altered active site flexibility and a structural metal-binding site in eukaryotic dutpase kinetic characterization, folding, and crystallographic studies of the homotrimeric drosophila enzyme
J Kovári, O Barabás, E Takács, A Békési, Z Dubrovay, V Pongrácz, ...
Journal of Biological Chemistry 279 (17), 17932-17944
2004
ORDERING OF THE'PEPTIDE-LIKE'C-TERMINUS OF DUTPASE UPON BINDING OF SUBSTRATE ANALOGUES: A HETERONUCLEAR NMR STUDY
Z Dubrovay, Z Gaspari, A Perczel, BG Vertessy
JOURNAL OF PEPTIDE SCIENCE 10, 223-223
2004
ENZYME CATALYSIS AND REGULATION-Multidimensional NMR Identifies the Conformational Shift Essential for Catalytic Competence in the 60-kDa Drosophila melanogaster dUTPase Trimer.
Z Dubrovay, Z Gaspari, E Hunyadi-Gulyas, KF Medzihradszky, A Perczel, …
Journal of Biological Chemistry 279 (17), 17945-17950
2004
ENZYME CATALYSIS AND REGULATION-Altered Active Site Flexibility and a Structural Metal-binding Site in Eukaryotic dUTPase. KINETIC CHARACTERIZATION, FOLDING, AND CRYSTALLOGRAPHIC STUDIES OF THE
J Kovari, O Barabas, E Takacs, A Bekesi, Z Dubrovay, V Pongracz, ...
Journal of Biological Chemistry 279 (17), 17932-17944
2004
dUTPase and nucleocapsid polypeptides of the Mason-Pfizer monkey virus form a fusion protein in the virion with homotrimeric organization and low catalytic efficiency
O Barabás, M Rumlová, A Erdei, V Pongrácz, I Pichová, BG Vértessy
Journal of Biological Chemistry 278 (40), 38803-38812
2003
Catalytic and structural role of the metal ion in dUTP pyrophosphatase
D Mustafi, A Bekesi, BG Vertessy, MW Makinen
Proceedings of the National Academy of Sciences 100 (10), 5670-5675
2003
PROTEIN STRUCTURE AND FOLDING-dUTPase and Nucleocapsid Polypeptides of the Mason-Pfizer Monkey Virus Form a Fusion Protein in the Virion with Homotrimeric Organization and Low Catalytic Efficiency.
O Barabas, M Rumlova, A Erdei, V Pongracz, I Pichova, BG Vertessy
Journal of Biological Chemistry 278 (40), 38803-38812
2003
Characterization of conformational properties of protein/trehalose/water system by neutron scattering
A Brandt, S Magazu, A Mangione, F Migliardo, BG Vertessy
Applied Physics A 74 (1), s457-s458
2002
Conformational studies of poly (ethylene oxide) in crystalline, molten, and solution phase
C Branca, S Magazu, G Maisano, F Migliardo, P Migliardo, G Romeo, …
Molecular Crystals and Liquid Crystals 372 (1), 17-23
2002
dUTPases: Essential factors in preventive DNA care-Preface
BG Vertessy
CURRENT PROTEIN & PEPTIDE SCIENCE 2 (4)
2001
Altered subunit communication in subfamilies of trimeric dUTPases
A Fiser, BG Vértessy
Biochemical and biophysical research communications 279 (2), 534-542
2000
A new potent calmodulin antagonist with arylalkylamine structure: crystallographic, spectroscopic and functional studies
V Harmat, Z Böcskei, G Náray-Szabó, I Bata, AS Csutor, I Hermecz, …
Journal of molecular biology 297 (3), 747-755
2000
Pyruvate Kinase as a Microtubule Destabilizing Factorin Vitro
BG Vértessy, D Bánkfalvi, J Kovács, P Löw, A Lehotzky, J Ovádi
Biochemical and biophysical research communications 254 (2), 430-435
1999
Simultaneous binding of drugs with different chemical structures to Ca2+-calmodulin: crystallographic and spectroscopic studies
BG Vertessy, V Harmat, Z Böcskei, G Náray-Szabó, F Orosz, J Ovádi
Biochemistry 37 (44), 15300-15310
1998
The complete triphosphate moiety of non-hydrolyzable substrate analogues is required for a conformational shift of the flexible C-terminus in E. coli dUTP pyrophosphatase
BG Vertessy, G Larsson, T Persson, AC Bergman, R Persson, PO Nyman
FEBS letters 421 (1), 83-88
1998
Alternative Binding of Two Sequential Glycolytic Enzymes to Microtubules MOLECULAR STUDIES IN THE PHOSPHOFRUCTOKINASE/ALDOLASE/MICROTUBULE SYSTEM
BG Vértessy, F Orosz, J Kovács, J Ovádi
Journal of Biological Chemistry 272 (41), 25542-25546
1997
Flexible glycine rich motif of Escherichia coli deoxyuridine triphosphate nucleotidohydrolase is important for functional but not for structural integrity of the enzyme
BG Vertessy
Proteins: Structure, Function, and Bioinformatics 28 (4), 568-579
1997
The interaction of a new anti‐tumour drug, KAR‐2 with calmodulin
F Orosz, BG Vértessy, C Salerno, C Crifo, E Capuozzo, J Ovádi
British journal of pharmacology 121 (5), 955-962
1997
Interaction of a new bis‐indol derivative, KAR‐2 with tubulin and its antimitotic activity
F Orosz, J Kovács, P Löw, BG Vértessy, Z Urbányi, T Ács, T Keve, J Ovádi
British journal of pharmacology 121 (5), 947-954
1997
Crystallization and preliminary diffraction analysis of Ca2+‐calmodulin‐drug and apocalmodulin‐drug complexes
BG Vertessy, Z Böcskei, V Harmath, G Náray‐Szabó, J Ovádi
Proteins: Structure, Function, and Bioinformatics 28 (1), 131-134
1997
Characterization of microtubule-phosphofructokinase complex: specific effects of MgATP and vinblastine
BG Vértessy, J Kovács, P Löw, A Lehotzky, A Molnár, F Orosz, J Ovádi
Biochemistry 36 (8), 2051-2062
1997
Triosephosphate isomerase deficiency: predictions and facts
F Orosz, BG Vértessy, S Hollán, M Horányi, J Ovádi
Journal of theoretical biology 182 (3), 437-447
1996
Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site
BG Vertessy, R Persson, AM Rosengren, M Zeppezauer, PO Nyman
Biochemical and biophysical research communications 219 (2), 294-300
1996
Specific characteristics of phosphofructokinase‐microtubule interaction
BG Vértessy, J Kovács, J Ovádi
FEBS letters 379 (2), 191-195
1996
Kinetic power, and theory of control
T Keleti, B Vértessy
Dynamics of Biochemical Systems, edited by S. Damjanovich, T. Keleti and L …
1996
Functional role of the C-terminal flexible arm of E. coli deoxyuridine triphosphatase
BG Vertessy
Progress in Biophysics and Molecular Biology, 219
1996
Anti-calmodulin potency of indol alkaloids in in vitro systems
A Molnár, K Liliom, F Orosz, BG Vértessy, J Ovádi
European Journal of Pharmacology: Molecular Pharmacology 291 (2), 73-82
1995
Identification of tyrosing as an active site residue involved in the catalytic mechanism of Escherichia coli dUTPase
BG Vertessy, M Zeppezauer
Biochemical Society Transactions 22 (2), 233S-233S
1994
Identification of tyrosine as a functional residue in the active site of Escherichia coli dUTPase
BG Vertessy, P Zalud, PO Nyman, M Zeppezauer
Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …
1994
Metabolite channeling versus free diffusion: reinterpretation of aldolase-catalysed inactivation of glyceraldehyde-3-phosphate dehydrogenase.
BG Vértessy, M Vas
Biochemical Journal 286 (Pt 3), 977
1992
Modulation of the interaction between aldolase and glycerol-phosphate dehydrogenase by fructose phosphates
BG Vértessy, F Orosz, J Ovádi
Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …
1991
Elasticity of the human red cell membrane skeleton. Effects of temperature and denaturants.
BG Vertessy, TL Steck
Biophysical journal 55 (2), 255
1989
Transient-time analysis of substrate-channelling in interacting enzyme systems
J Ovádi, P Tompa, B Vértessy, F Orosz, T Keleti, GR Welch
Biochemical Journal 257 (1), 187-190
1989
The perfection of substrate-channelling in interacting enzyme systems: Energetics and evolution
T Keleti, B Vértessy, GR Welch
Journal of theoretical biology 135 (1), 75-83
1988
The control of cell metabolism for homogeneous vs. heterogeneous enzyme systems
GR Welch, T Keleti, B Vértessy
Journal of theoretical biology 130 (4), 407-422
1988
A simple approach to detect active‐site‐directed enzyme‐enzyme interactions
B VÉRTESSY, J OVÁDI
European Journal of Biochemistry 164 (3), 655-659
1987
Microenvironment of the enzyme-bound NADH is different in lobster and pig muscle glyceraldehyde-3-phosphate dehydrogenase microcrystals
B Vértessy, M Vas, T Keleti
Archives of biochemistry and biophysics 251 (1), 299-305
1986
Dynamics of Biochemical Systems
T Keleti, B Vértessy, S Damjanovich, T Keleti, L Trón
Symp. Biol. Hung. 30, 3
1986

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