Publications

 

Publications 12Publications 2Publications 32Publications 4Publications 5Publications 02

 

 

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Perturbation of genome integrity to fight pathogenic microorganisms
K Nyíri, BG Vértessy
Biochimica et Biophysica Acta (BBA)-General Subjects
doi:10.1016/j.bbagen.2016.05.024
  2016
Secondary Structure Prediction of Protein Constructs Using Random Incremental Truncation and Vacuum-Ultraviolet CD Spectroscopy
M Pukáncsik, Á Orbán, K Nagy, K Matsuo, K Gekko, D Maurin, D Hart, I Kézsmárki, BG. Vertessy
doi: 10.1371/journal.pone.0156238  
  2016
Trading in cooperativity for specificity to maintain uracil-free DNA
JE Szabó, E Takács, G Merényi, BG Vértessy, J Tóth
Scientific Reports 6, Article number: 24219
doi:10.1038/srep24219
  2016
Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich, ...
Autophagy 12 (1), 1-222
  2016
Exploring the role of the phage-specific insert of bacteriophage Φ11 dUTPase
K Nyíri, V Papp-Kádár, JE Szabó, V Németh, BG Vértessy
Structural Chemistry 26 (5-6), 1425-1432
  2015
Structural characterization of a complex derived from lead (II) perchlorate and acridono-18-crown-6 ether
T Németh, Á Golcs, I Leveles, T Tóth, BG Vértessy, P Huszthy
Structural Chemistry 26 (5-6), 1467-1471
  2015
Cover Picture: Phenylalanine Ammonia‐Lyase‐Catalyzed Deamination of an Acyclic Amino Acid: Enzyme Mechanistic Studies Aided by a Novel Microreactor Filled with Magnetic Nanoparticles (ChemBioChem 16/2015)
D Weiser, LC Bencze, G Bánóczi, F Ender, R Kiss, E Kókai, A Szilágyi, ...
ChemBioChem 16 (16), 2257-2257
  2015
Phenylalanine Ammonia‐Lyase‐Catalyzed Deamination of an Acyclic Amino Acid: Enzyme Mechanistic Studies Aided by a Novel Microreactor Filled with Magnetic Nanoparticles
D Weiser, LC Bencze, G Bánóczi, F Ender, R Kiss, E Kókai, A Szilágyi, ...
ChemBioChem 16 (16), 2283-2288
  2015
Structural biology and regulation of protein import into the nucleus
M Christie, CW Chang, G Róna, KM Smith, AG Stewart, AAS Takeda, ...
Journal of molecular biology
  2015
Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications
G Róna, I Scheer, K Nagy, HL Pálinkás, G Tihanyi, M Borsos, A Békési, ...
Nucleic acids research, gkv977
  2015
Evidence-based structural model of the Staphylococcal repressor protein: separation of functions into different domains
K Nyíri, B Kőhegyi, A Micsonai, J Kardos, BG Vertessy
PloS one 10 (9), e0139086
  2015
Life without dUTPase
C Kerepesi, JE Szabó, V Grolmusz, BG Vértessy
arXiv preprint arXiv:1509.04850
  2015
Cross-species inhibition of dUTPase via the Staphylococcal Stl protein perturbs dNTP pool and colony formation in Mycobacterium
R Hirmondó, JE Szabó, K Nyíri, S Tarjányi, P Dobrotka, J Tóth, ...
DNA repair 30, 21-27
  2015
Antimycobacterial activity of peptide conjugate of pyridopyrimidine derivative against Mycobacterium tuberculosis in a series of in vitro and in vivo models
K Horváti, B Bacsa, N Szabó, K Fodor, G Balka, M Rusvai, É Kiss, G Mező, ...
Tuberculosis 95, S207-S211
  2015
Molecular mechanism for the thermo-sensitive phenotype of CHO-MT58 cell line harbouring a mutant CTP: phosphocholine cytidylyltransferase
L Marton, GN Nagy, O Ozohanics, A Lábas, B Krámos, J Oláh, K Vékey, ...
PloS one 10 (6), e0129632
  2015
dUTPase expression correlates with cell division potential in Drosophila melanogaster
A Horváth, J Batki, L Henn, T Lukacsovich, G Róna, M Erdélyi, ...
FEBS Journal 282 (10), 1998-2013
  2015
Mutations decouple proton transfer from phosphate cleavage in the dutpase catalytic reaction
A Lopata, PG Jambrina, PK Sharma, BR Brooks, J Toth, BG Vertessy, ...
ACS Catalysis 5 (6), 3225-3237
  2015
Immobilization of Phenylalanine Ammonia‐Lyase on Single‐Walled Carbon Nanotubes for Stereoselective Biotransformations in Batch and Continuous‐Flow Modes
JH Bartha‐Vári, MI Toşa, FD Irimie, D Weiser, Z Boros, BG Vértessy, ...
ChemCatChem 7 (7), 1122-1128
  2015
NLS copy‐number variation governs efficiency of nuclear import–case study on dUTPases
G Róna, HL Pálinkás, M Borsos, A Horváth, I Scheer, A Benedek, ...
FEBS Journal 281 (24), 5463-5478
  2014
Composite aromatic boxes for enzymatic transformations of quaternary ammonium substrates
GN Nagy, L Marton, A Contet, O Ozohanics, LM Ardelean, Á Révész, ...
Angewandte Chemie International Edition 53 (49), 13471-13476
  2014
Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation
G Róna, M Borsos, JJ Ellis, AM Mehdi, M Christie, Z Környei, M Neubrandt, ...
Cell cycle 13 (22), 3551-3564
  2014
Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control
JE Szabó, V Németh, V Papp-Kádár, K Nyíri, I Leveles, ÁÁ Bendes, ...
Nucleic acids research 42 (19), 11912-11920
  2014
Factors influencing nucleo-cytoplasmic trafficking: which matter? Response to Alvisi & Jans' comment on Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights
G Róna, M Borsos, B Kobe, BG Vértessy
Acta Crystallographica Section D: Biological Crystallography 70 (10), 2777-2778
  2014
Insights into the catalytic mechanism of PfECT by thermodynamic, kinetic and structural analyses
A Contet, S Maheshwari, E Pihan, GN Nagy, B Vertessy, D Douguet, ...
FEBS JOURNAL 281, 574-575
  2014
Preventive DNA repair by sanitizing the cellular (deoxy) nucleoside triphosphate pool
GN Nagy, I Leveles, BG Vértessy
FEBS Journal 281 (18), 4207-4223
  2014
The metagenomic telescope
B Szalkai, I Scheer, K Nagy, BG Vertessy, V Grolmusz
PloS one 9 (7), e101605
  2014
Bisepoxide Cross‐Linked Enzyme Aggregates—New Immobilized Biocatalysts for Selective Biotransformations
D Weiser, A Varga, K Kovács, F Nagy, A Szilágyi, BG Vértessy, C Paizs, ...
ChemCatChem 6 (5), 1463-1469
  2014
Expression and properties of the highly alkalophilic phenylalanine ammonia-lyase of thermophilic Rubrobacter xylanophilus
K Kovacs, G Banoczi, A Varga, I Szabo, A Holczinger, G Hornyanszky, ...
PloS one 9 (1), e85943
  2014
A preventív DNS-hibajavítás szerkezeti biológiája
G Vértessy
MAGYAR KÉMIAI FOLYÓIRAT-KÉMIAI KÖZLEMÉNYEK 120 (4), 176-177
  2014
Structure and enzymatic mechanism of a moonlighting dUTPase
I Leveles, V Németh, JE Szabó, V Harmat, K Nyíri, ÁÁ Bendes, ...
Acta Crystallographica Section D: Biological Crystallography 69 (12), 2298-2308
  2013
Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights
G Róna, M Marfori, M Borsos, I Scheer, E Takács, J Tóth, F Babos, ...
Acta Crystallographica Section D: Biological Crystallography 69 (12), 2495-2505
  2013
Investigations of homologous disaccharides by elastic incoherent neutron scattering and wavelet multiresolution analysis
S Magazù, F Migliardo, BG Vertessy, MT Caccamo
Chemical Physics 424, 56-61
  2013
Protein dynamics by neutron scattering: The protein dynamical transition and the fragile-to-strong dynamical crossover in hydrated lysozyme
S Magazù, F Migliardo, A Benedetto, B Vertessy
Chemical Physics 424, 26-31
  2013
Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling
O Barabás, V Németh, A Bodor, A Perczel, E Rosta, Z Kele, I Zagyva, ...
Nucleic acids research, gkt756
  2013
Genomic integrity of virulence genes is preserved by a dUTPase-based molecular switch
J Szabo, V Nemeth, V Papp-Kadar, K Nyiri, I Leveles, A Bendes, ...
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 42, S134-S134
  2013
Evolutionary and mechanistic insights into substrate and product accommodation of CTP: phosphocholine cytidylyltransferase from Plasmodium falciparum
GN Nagy, L Marton, B Krámos, J Oláh, Á Révész, K Vékey, F Delsuc, ...
FEBS Journal 280 (13), 3132-3148
  2013
Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis
A Butykai, A Orbán, V Kocsis, D Szaller, S Bordács, E Tátrai-Szekeres, ...
Scientific reports 3
  2013
Nanomechanics of the MPMV Capsid-Protein-Binding RNA Fragment
M Simon, Z Martonfalvi, P Bianco, B Vertessy, MSZ Kellermayer
Biophysical Journal 104 (2), 168a-169a
  2013
Silicon carbide quantum dots for bioimaging
D Beke, Z Szekrényes, D Pálfi, G Róna, I Balogh, PA Maák, G Katona, ...
Journal of Materials Research 28 (02), 205-209
  2013
Egy tudományos hungarikum: a fluktuációs fit
F Orosz, G Vértessy
Magyar Tudomány 174 (2), 170-175
  2013
An inter-species landscape of DNA repair proteins based on extreme metagenomes and repeated HMM profiling
V Grolmusz, B Szalkai, G Vértessy, I Scher
FEBS Journal 280 (Supl 1), 66
  2013
dUTPase based switch controls transfer of virulence genes in order to preserve integrity of the transferred mobile genetic elements
JE Szabó, V Németh-Pongrácz, V Papp-Kádár, K Nyíri, B Besztercei, ...
FEBS Journal 280 (Supl 1), 59-60
  2013
The impact of dUTPase expression on genome integrity
A Horváth, J Batki, V Muha, G Róna, P Vilmos, M Erdélyi, G Vértessy
FEBS Journal 280 (Supl 1), 58-59
  2013
Molecular cloning and characterization of a thermostable esterase/lipase produced by a novel Anoxybacillus flavithermus strain
L Chiş, F Hriscu, M, Bica, A, Toşa, M, Nagy, Gergely, Róna
J Gen Appl Microbiol. 59 (2), 119-134
  2013
Expanding the DNA alphabet in the fruit fly: Uracil enrichment in genomic DNA
A Horváth, A Békési, V Muha, M Erdélyi, BG Vértessy
Fly 7 (1), 23-27
  2013
Molecular Mechanisms of Survival Strategies in Extreme Conditions
S Magazù, F Migliardo, MA Gonzalez, C Mondelli, SF Parker, BG Vertessy
Life 2 (4), 364-376
  2012
Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvement
V Muha, A Horváth, A Békési, M Pukáncsik, B Hodoscsek, G Merényi, ...
PLoS Genet 8 (6), e1002738
  2012
The dUTPase enzyme is essential in Mycobacterium smegmatis
I Pecsi, R Hirmondo, AC Brown, A Lopata, T Parish, BG Vertessy, J Tóth
PLoS One 7 (5), e37461
  2012
Enhanced cellular uptake of a new, in silico identified antitubercular candidate by peptide conjugation
K Horváti, B Bacsa, N Szabó, S Dávid, G Mező, V Grolmusz, B Vértessy, ...
Bioconjugate chemistry 23 (5), 900-907
  2012
Preparation of unnatural amino acids with ammonia-lyases and 2, 3-aminomutases
L Poppe, C Paizs, K Kovács, FD Irimie, B Vértessy
Unnatural Amino Acids: Methods and Protocols, 3-19
  2012
Discovery of novel MDR-Mycobacterium tuberculosis inhibitor by new FRIGATE computational screen
C Scheich, Z Szabadka, B Vértessy, V Pütter, V Grolmusz, M Schade
PloS one 6 (12), e28428
  2011
Crystallization and preliminary crystallographic analysis of dUTPase from the φ11 helper phage of Staphylococcus aureus
I Leveles, G Róna, I Zagyva, A Bendes, V Harmat, BG Vértessy
Acta Crystallographica Section F: Structural Biology and Crystallization ...
  2011
One-step method for quantitative determination of uracil in DNA by real-time PCR
BG Vertessy, A Horvath, V Grolmusz
US Patent App. 13/237,987
  2011
Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination
I Pécsi, JE Szabó, SD Adams, I Simon, JR Sellers, BG Vértessy, J Tóth
Proceedings of the National Academy of Sciences 108 (35), 14437-14442
  2011
Nanomechanical manipulation of Mason-Pfizer monkey retroviral RNA fragment with optical tweezers
M Simon, Z Martonfalvi, P Bianco, B Vertessy, M Kellermayer
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 40, 223-223
  2011
Proteins with Complex Architecture as Potential Targets for Drug Design: A Case Study of Mycobacterium tuberculosis
B Mészáros, J Tóth, BG Vértessy, Z Dosztányi, I Simon
PLoS Comput Biol 7 (7), e1002118
  2011
Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism
G Merényi, J Kovári, J Tóth, E Takács, I Zagyva, A Erdei, BG Vértessy
Nucleosides, Nucleotides and Nucleic Acids 30 (6), 369-390
  2011
Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide
Z Bozóky, G Róna, É Klement, KF Medzihradszky, G Merényi, ...
PloS one 6 (5), e19546
  2011
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans
P Erdélyi, É Borsos, K Takács-Vellai, T Kovács, AL Kovács, T Sigmond, ...
Journal of cell science 124 (9), 1510-1518
  2011
Humán dUTPáz: kooperativitás és sejtbeli kölcsönhatások= Human dUTPase: cooperativity and cellular interactions
G Vértessy, O Barabás, A Horváth, A Málnási Csizmadia, V Németh, ...
OTKA Kutatási Jelentések| OTKA Research Reports
  2011
Association of RNA with the uracil‐DNA‐degrading factor has major conformational effects and is potentially involved in protein folding
A Bekesi, M Pukancsik, P Haasz, L Felfoldi, I Leveles, V Muha, ...
FEBS journal 278 (2), 295-315
  2011
From “fluctuation fit” to “conformational selection”: evolution, rediscovery, and integration of a concept
BG Vertessy, F Orosz
Bioessays 33 (1), 30-34
  2011
EXPRESSION OF PHENYLALANINE AMMONIA-LYASES IN ESCHERICHIA COLI STRAINS.
K Kovács, A Holczinger, B Vértessy, L Poppe
Studia Universitatis Babes-Bolyai, Chemia
  2010
A one-step method for quantitative determination of uracil in DNA by real-time PCR
A Horváth, BG Vértessy
Nucleic acids research 38 (21), e196-e196
  2010
Structure and mechanism of calmodulin binding to a signaling sphingolipid reveal new aspects of lipid-protein interactions
E Kovacs, V Harmat, J Tóth, BG Vértessy, K Módos, J Kardos, K Liliom
The FASEB Journal 24 (10), 3829-3839
  2010
Sphingosylphosphorylcholine Binds to Calmodulin and Inhibits Its Function
E Kovacs, V Harmat, J Toth, B Vertessy, K Modos, J Kardos, K LILIOM
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 382, 20-20
  2010
Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases
E Takács, G Nagy, I Leveles, V Harmat, A Lopata, J Tóth, BG Vértessy
FEBS letters 584 (14), 3047-3054
  2010
Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase
I Pecsi, I Leveles, V Harmat, BG Vertessy, J Toth
Nucleic acids research, gkq584
  2010
Drosophila proteins involved in metabolism of uracil‐DNA possess different types of nuclear localization signals
G Merényi, E Kónya, BG Vértessy
FEBS journal 277 (9), 2142-2156
  2010
Physiological truncation and domain organization of a novel uracil‐DNA‐degrading factor
M Pukáncsik, A Békési, É Klement, É Hunyadi‐Gulyás, KF Medzihradszky, ...
FEBS journal 277 (5), 1245-1259
  2010
Study of solvent–protein coupling effects by neutron scattering
B Varga, F Migliardo, E Takacs, B Vertessy, S Magazù, MTF Telling
Journal of biological physics 36 (2), 207-220
  2010
The Role of P-loop in the Enzymatic Mechanism of Nucleotide Pyrophosphatases
I Pecsi, JE Szabo, BG Vertessy, J Toth
Biophysical Journal 98 (3), 449a
  2010
Phosphorylation Dependent Nuclear Transport of Human Dutpase
G Rona, E Takacs, Z Bozoky, Z Kornyei, M Neubrandt, J Toth, I Scheer, ...
Biophysical Journal 98 (3), 309a
  2010
Peculiar Regulatory Role of Magnesium in Nucleotide Hydrolysis of dUTPases
E Takacs, BG Vertessy, J Toth
Biophysical Journal 98 (3), 451a
  2010
New Aspects of Lipid-Protein Interactions Revealed by Calmodulin Binding to the Lipid Mediator Sphingosylphosphorylcholine
E Kovacs, V Harmat, J Toth, BG Vertessy, K Modos, J Kardos, K Liliom
Biophysical Journal 98 (3), 675a
  2010
Dissociation of Calmodulin-Target Peptide Complexes by the Lipid Mediator Sphingosylphosphorylcholine IMPLICATIONS IN CALCIUM SIGNALING
E Kovacs, J Tóth, BG Vértessy, K Liliom
Journal of Biological Chemistry 285 (3), 1799-1808
  2010
Ansari MA, 341 Arnold U, 331 Arora A, 341
RG Atkinson, W Becker, F Beisson, A Bekesi, H Benyamini, A Bergemann, ...
FEBS Journal 278, 401
  2010
Nuclear localization signal-dependent and-independent movements of Drosophila melanogaster dUTPase isoforms during nuclear cleavage
V Muha, I Zagyva, Z Venkei, J Szabad, BG Vértessy
Biochemical and biophysical research communications 381 (2), 271-275
  2009
Molecular shape and prominent role of β-strand swapping in organization of dUTPase oligomers
E Takács, O Barabás, MV Petoukhov, DI Svergun, BG Vértessy
FEBS letters 583 (5), 865-871
  2009
Improving thermostability and catalytic activity of pyranose 2‐oxidase from Trametes multicolor by rational and semi‐rational design
O Spadiut, C Leitner, C Salaheddin, B Varga, BG Vertessy, TC Tan, ...
Febs Journal 276 (3), 776-792
  2009
Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases
BG Vértessy, J Tóth
Accounts of chemical research 42 (1), 97-106
  2008
Experimental study on dUTPase-inhibitor candidate and dUTPase/disaccharide mixtures by PCS and ENS
B Varga, F Migliardo, E Takacs, B Vertessy, S Magazù
Journal of Molecular Structure 886 (1), 128-135
  2008
Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor
B Varga, O Barabás, E Takács, N Nagy, P Nagy, BG Vértessy
Biochemical and biophysical research communications 373 (1), 8-13
  2008
Peptide conjugates of new in silico identified drug candidates and first/second line antituberculars-design, synthesis and antimycobacterial effect
K Horvati, G Mezo, N Szabo, B Vertessy, B Varga, V Grolmusz, F Hudecz, ...
JOURNAL OF PEPTIDE SCIENCE 14 (8), 161-161
  2008
Neutron scattering studies on dUTPase complex in the presence of bioprotectant systems
B Varga, F Migliardo, E Takacs, B Vertessy, S Magazù, C Mondelli
Chemical Physics 345 (2), 250-258
  2008
Methylene substitution at the α–β bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site
J Kovári, O Barabás, B Varga, A Békési, F Tölgyesi, J Fidy, J Nagy, ...
Proteins: Structure, Function, and Bioinformatics 71 (1), 308-319
  2008
Amphiphilic nature of new antitubercular drug candidates and their interaction with lipid monolayer
K Hill, CB Pénzes, BG Vértessy, Z Szabadka, V Grolmusz, É Kiss
Colloids for Nano-and Biotechnology, 87-92
  2008
Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme
J Tóth, B Varga, M Kovács, A Málnási-Csizmadia, BG Vértessy
Journal of Biological Chemistry 282 (46), 33572-33582
  2007
Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase
B Varga, O Barabás, J Kovári, J Tóth, É Hunyadi-Gulyás, É Klement, ...
FEBS letters 581 (24), 4783-4788
  2007
A novel fruitfly protein under developmental control degrades uracil-DNA
A Békési, M Pukáncsik, V Muha, I Zagyva, I Leveles, E Hunyadi-Gulyás, ...
Biochemical and biophysical research communications 355 (3), 643-648
  2007
Fémek szerepe a fehérjeszerkezetben és-működésben= The role of metals in protein structure and function
G Náray-Szabó, O Barabás, I Berente, A Czajlik, V Farkas, J Fidy, ...
OTKA Kutatási Jelentések| OTKA Research Reports
  2007
Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins
V Nemeth-Pongracz, O Barabas, M Fuxreiter, I Simon, I Pichová, ...
Nucleic acids research 35 (2), 495-505
  2007
Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance
SU Lari, CY Chen, BG Vertéssy, J Morré, SE Bennett
DNA repair 5 (12), 1407-1420
  2006
INOR 451-Kinetic effects of vanadium compounds on human dUTPase, the enzyme responsible for DNA integrity and involved in cancer cell survival
I Zagyva, O Barabas, J Smee, DC Crans, B Vertessy
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 232
  2006
Characterization of the nuclease responsible for uracil-DNA signalling in drosophila melanogaster
M Pukancsik, A Bekesi, F Felfoldi, I Zagyva, F Medzihradszky, G Vertessy
FEBS JOURNAL 273, 114-114
  2006
Cooperativity in human dUTPase homotrimer
B Varga, J Kovari, O Barabas, E Takacs, A Malnasi-Csizmadia, ...
FEBS JOURNAL 273, 192-192
  2006
Puzzles in formation of trimeric dUTPases
E Takacs, A Bekesi, B Vertessy
FEBS JOURNAL 273, 309-309
  2006
dUTpase MRNA silencing triggers apoptosis in cancer cells
J Kovari, I Zagyva, G Merenyi, BG Vertessy
FEBS JOURNAL 273, 113-113
  2006
A new family of nucleases: the uracil-DNA-specific nuclease of pupating insects
A Bekesi, F Felfoldi, M Pukancsik, V Maha, I Zagyva, I Leveles, ...
FEBS JOURNAL 273, 53-53
  2006
A retroviral dUTPase: modulatory effect of flexible segments on protein structure and function
V Nemeth, O Barabas, M Fuxreiter, D Svergun, M Petoukhov, BG Vertessy
FEBS JOURNAL 273, 312-312
  2006
Interacting partners of M-PMV nucleocapsid-dUTPase
V Nemeth-Pongracz, J Snasel, M Rumlova, I Pichova, BG Vertessy
Nucleosides, Nucleotides and Nucleic Acids 25 (9-11), 1197-1200
  2006
Crystallization and preliminary X-ray studies of dUTPase from Mason–Pfizer monkey retrovirus
O Barabás, V Németh, BG Vértessy
Acta Crystallographica Section F: Structural Biology and Crystallization …
  2006
Synthesis of URACIL-DNA specific endonuclease derived peptides for generation of enzyme specific antibodies
M Ligeti, A Bekesi, A Magyar, F Hudecz, BG Vertessy
Journal of Peptide Science 12, 155-155
  2006
Role of the C-terminal conserved sequence motif in the function of dUTPase from Mason-Pfizer monkey retrovirus
O Barabas, V Nemeth-Pongracz, A Magyar, F Hudecz, B Vértessy
J. Pept. Sci 12, 206
  2006
Same fold but altered responsivity in the evolution of dUTPase homotrimer
E Takacs, O Barabas, D Svergun, Z Dubrovay, VK Grolmusz, B Vertessy
FEBS JOURNAL 272, 100-100
  2005
Uracil-DNA nuclease: protein enzyme possessing nuclease activity specific for uracil containing nucleic acid, process for its preparation and methods of use
BG Vertessy, A Beke, F Felfoldi, VI Grolmusz, M Pukancsik
US Patent App. 11/160,040
  2005
Mechanistic studies of dUTPases
J Kovári, T Imre, P Szabó, BG Vértessy
Nucleosides, Nucleotides and Nucleic Acids 23 (8-9), 1475-1479
  2004
Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase
O Barabás, V Pongrácz, J Kovári, M Wilmanns, BG Vértessy
Journal of Biological Chemistry 279 (41), 42907-42915
  2004
Experimental observation of the pentacovalent intermediate in dUTPase: structural snapshots along the reaction coordinate
O Barábas, V Pongrácz, J Kovári, M Wilmanns, BG Vértessy
Acta Crystallographica Section A: Foundations of Crystallography 60 (a1 …
  2004
A tradeoff between protein stability and conformational mobility in homotrimeric dUTPases
E Takács, VK Grolmusz, BG Vértessy
FEBS letters 566 (1-3), 48-54
  2004
Developmental regulation of dUTPase in Drosophila melanogaster
A Békési, I Zagyva, É Hunyadi-Gulyás, V Pongrácz, J Kovári, ÁO Nagy, …
Journal of Biological Chemistry 279 (21), 22362-22370
  2004
Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer
Z Dubrovay, Z Gáspári, É Hunyadi-Gulyás, KF Medzihradszky, A Perczel, …
Journal of Biological Chemistry 279 (17), 17945-17950
  2004
Altered active site flexibility and a structural metal-binding site in eukaryotic dutpase kinetic characterization, folding, and crystallographic studies of the homotrimeric drosophila enzyme
J Kovári, O Barabás, E Takács, A Békési, Z Dubrovay, V Pongrácz, ...
Journal of Biological Chemistry 279 (17), 17932-17944
  2004
ORDERING OF THE'PEPTIDE-LIKE'C-TERMINUS OF DUTPASE UPON BINDING OF SUBSTRATE ANALOGUES: A HETERONUCLEAR NMR STUDY
Z Dubrovay, Z Gaspari, A Perczel, BG Vertessy
JOURNAL OF PEPTIDE SCIENCE 10, 223-223
  2004
ENZYME CATALYSIS AND REGULATION-Multidimensional NMR Identifies the Conformational Shift Essential for Catalytic Competence in the 60-kDa Drosophila melanogaster dUTPase Trimer.
Z Dubrovay, Z Gaspari, E Hunyadi-Gulyas, KF Medzihradszky, A Perczel, …
Journal of Biological Chemistry 279 (17), 17945-17950
  2004
ENZYME CATALYSIS AND REGULATION-Altered Active Site Flexibility and a Structural Metal-binding Site in Eukaryotic dUTPase. KINETIC CHARACTERIZATION, FOLDING, AND CRYSTALLOGRAPHIC STUDIES OF THE
J Kovari, O Barabas, E Takacs, A Bekesi, Z Dubrovay, V Pongracz, ...
Journal of Biological Chemistry 279 (17), 17932-17944
  2004
dUTPase and nucleocapsid polypeptides of the Mason-Pfizer monkey virus form a fusion protein in the virion with homotrimeric organization and low catalytic efficiency
O Barabás, M Rumlová, A Erdei, V Pongrácz, I Pichová, BG Vértessy
Journal of Biological Chemistry 278 (40), 38803-38812
  2003
Catalytic and structural role of the metal ion in dUTP pyrophosphatase
D Mustafi, A Bekesi, BG Vertessy, MW Makinen
Proceedings of the National Academy of Sciences 100 (10), 5670-5675
  2003
PROTEIN STRUCTURE AND FOLDING-dUTPase and Nucleocapsid Polypeptides of the Mason-Pfizer Monkey Virus Form a Fusion Protein in the Virion with Homotrimeric Organization and Low Catalytic Efficiency.
O Barabas, M Rumlova, A Erdei, V Pongracz, I Pichova, BG Vertessy
Journal of Biological Chemistry 278 (40), 38803-38812
  2003
Characterization of conformational properties of protein/trehalose/water system by neutron scattering
A Brandt, S Magazu, A Mangione, F Migliardo, BG Vertessy
Applied Physics A 74 (1), s457-s458
  2002
Conformational studies of poly (ethylene oxide) in crystalline, molten, and solution phase
C Branca, S Magazu, G Maisano, F Migliardo, P Migliardo, G Romeo, …
Molecular Crystals and Liquid Crystals 372 (1), 17-23
  2002
dUTPases: Essential factors in preventive DNA care-Preface
BG Vertessy
CURRENT PROTEIN & PEPTIDE SCIENCE 2 (4)
  2001
Altered subunit communication in subfamilies of trimeric dUTPases
A Fiser, BG Vértessy
Biochemical and biophysical research communications 279 (2), 534-542
  2000
A new potent calmodulin antagonist with arylalkylamine structure: crystallographic, spectroscopic and functional studies
V Harmat, Z Böcskei, G Náray-Szabó, I Bata, AS Csutor, I Hermecz, …
Journal of molecular biology 297 (3), 747-755
  2000
Pyruvate Kinase as a Microtubule Destabilizing Factorin Vitro
BG Vértessy, D Bánkfalvi, J Kovács, P Löw, A Lehotzky, J Ovádi
Biochemical and biophysical research communications 254 (2), 430-435
  1999
Simultaneous binding of drugs with different chemical structures to Ca2+-calmodulin: crystallographic and spectroscopic studies
BG Vertessy, V Harmat, Z Böcskei, G Náray-Szabó, F Orosz, J Ovádi
Biochemistry 37 (44), 15300-15310
  1998
The complete triphosphate moiety of non-hydrolyzable substrate analogues is required for a conformational shift of the flexible C-terminus in E. coli dUTP pyrophosphatase
BG Vertessy, G Larsson, T Persson, AC Bergman, R Persson, PO Nyman
FEBS letters 421 (1), 83-88
  1998
Alternative Binding of Two Sequential Glycolytic Enzymes to Microtubules MOLECULAR STUDIES IN THE PHOSPHOFRUCTOKINASE/ALDOLASE/MICROTUBULE SYSTEM
BG Vértessy, F Orosz, J Kovács, J Ovádi
Journal of Biological Chemistry 272 (41), 25542-25546
  1997
Flexible glycine rich motif of Escherichia coli deoxyuridine triphosphate nucleotidohydrolase is important for functional but not for structural integrity of the enzyme
BG Vertessy
Proteins: Structure, Function, and Bioinformatics 28 (4), 568-579
  1997
The interaction of a new anti‐tumour drug, KAR‐2 with calmodulin
F Orosz, BG Vértessy, C Salerno, C Crifo, E Capuozzo, J Ovádi
British journal of pharmacology 121 (5), 955-962
  1997
Interaction of a new bis‐indol derivative, KAR‐2 with tubulin and its antimitotic activity
F Orosz, J Kovács, P Löw, BG Vértessy, Z Urbányi, T Ács, T Keve, J Ovádi
British journal of pharmacology 121 (5), 947-954
  1997
Crystallization and preliminary diffraction analysis of Ca2+‐calmodulin‐drug and apocalmodulin‐drug complexes
BG Vertessy, Z Böcskei, V Harmath, G Náray‐Szabó, J Ovádi
Proteins: Structure, Function, and Bioinformatics 28 (1), 131-134
  1997
Characterization of microtubule-phosphofructokinase complex: specific effects of MgATP and vinblastine
BG Vértessy, J Kovács, P Löw, A Lehotzky, A Molnár, F Orosz, J Ovádi
Biochemistry 36 (8), 2051-2062
  1997
Triosephosphate isomerase deficiency: predictions and facts
F Orosz, BG Vértessy, S Hollán, M Horányi, J Ovádi
Journal of theoretical biology 182 (3), 437-447
  1996
Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site
BG Vertessy, R Persson, AM Rosengren, M Zeppezauer, PO Nyman
Biochemical and biophysical research communications 219 (2), 294-300
  1996
Specific characteristics of phosphofructokinase‐microtubule interaction
BG Vértessy, J Kovács, J Ovádi
FEBS letters 379 (2), 191-195
  1996
Kinetic power, and theory of control
T Keleti, B Vértessy
Dynamics of Biochemical Systems, edited by S. Damjanovich, T. Keleti and L …
  1996
Functional role of the C-terminal flexible arm of E. coli deoxyuridine triphosphatase
BG Vertessy
Progress in Biophysics and Molecular Biology, 219
  1996
Anti-calmodulin potency of indol alkaloids in in vitro systems
A Molnár, K Liliom, F Orosz, BG Vértessy, J Ovádi
European Journal of Pharmacology: Molecular Pharmacology 291 (2), 73-82
  1995
Identification of tyrosing as an active site residue involved in the catalytic mechanism of Escherichia coli dUTPase
BG Vertessy, M Zeppezauer
Biochemical Society Transactions 22 (2), 233S-233S
  1994
Identification of tyrosine as a functional residue in the active site of Escherichia coli dUTPase
BG Vertessy, P Zalud, PO Nyman, M Zeppezauer
Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …
  1994
Metabolite channeling versus free diffusion: reinterpretation of aldolase-catalysed inactivation of glyceraldehyde-3-phosphate dehydrogenase.
BG Vértessy, M Vas
Biochemical Journal 286 (Pt 3), 977
  1992
Modulation of the interaction between aldolase and glycerol-phosphate dehydrogenase by fructose phosphates
BG Vértessy, F Orosz, J Ovádi
Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …
  1991
Elasticity of the human red cell membrane skeleton. Effects of temperature and denaturants.
BG Vertessy, TL Steck
Biophysical journal 55 (2), 255
  1989
Transient-time analysis of substrate-channelling in interacting enzyme systems
J Ovádi, P Tompa, B Vértessy, F Orosz, T Keleti, GR Welch
Biochemical Journal 257 (1), 187-190
  1989
The perfection of substrate-channelling in interacting enzyme systems: Energetics and evolution
T Keleti, B Vértessy, GR Welch
Journal of theoretical biology 135 (1), 75-83
  1988
The control of cell metabolism for homogeneous vs. heterogeneous enzyme systems
GR Welch, T Keleti, B Vértessy
Journal of theoretical biology 130 (4), 407-422
  1988
A simple approach to detect active‐site‐directed enzyme‐enzyme interactions
B VÉRTESSY, J OVÁDI
European Journal of Biochemistry 164 (3), 655-659
  1987
Microenvironment of the enzyme-bound NADH is different in lobster and pig muscle glyceraldehyde-3-phosphate dehydrogenase microcrystals
B Vértessy, M Vas, T Keleti
Archives of biochemistry and biophysics 251 (1), 299-305
  1986
Dynamics of Biochemical Systems
T Keleti, B Vértessy, S Damjanovich, T Keleti, L Trón
Symp. Biol. Hung. 30, 3
  1986

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