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The current projects cover the following objects of study  



Importin alpha and its complexes

Aim: to study the molecular and mechanistic details of nucleo-cytoplasmic trafficking.



Plasmodium falciparum CTP: cytidylyltransferase

Aim: to understand species-specific inhibition allowing drug design.




Staphylococcus aureus phage dUTPase and promoter regulatory element Stl1

 Aim: to provide insight into regulation of pathogenicity island gene expression.




Mycobacterium tuberculosis dUTPase

Aim: species-specifc drug design.




Human dUTPase

Aim: to understand uracil-DNS metabolism in humans.



Drosophila uracil-DNA degrading factor

Aim: to understand the role of uracil-substituted DNA in metamorphosis.




 RNA silencing supressor P1

 Aim: Structural studies of the viral RNA silencing suppressor P1: Molecular determinants of Argonaute target cleavage inhibition